As pain management evolves with advanced techniques and stricter payer rules, accurate pain management CPT codes have never been more critical. In 2025, billing errors don’t just mean claim denials; they mean financial loss, audits, and even compliance risks. Clinics that stay updated with coding changes will thrive, while those using outdated codes risk costly penalties.
In this blog, you’ll get a detailed 2025 guide to pain management CPT codes, including new updates, key ICD-10 links, and real examples to improve claim success rates.
Pain management has become innovative with slightly invasive practices like:
New CPT codes reflect this evolution and now bundle imaging guidance, simplify descriptor language, and support precision-based care.
To understand principal pain management CPT codes, know the structure and categories:
CPT Code | Description |
20552 | Trigger point injection, 1–2 muscle groups |
20553 | Trigger point injection, ≥3 muscle groups |
20610 | Major joint injection (e.g., shoulder, knee) |
64405 | Greater occipital nerve block |
64466 | Thoracic Fascial plane block (unilateral) |
64467 | Thoracic plane continuous infusion |
64473 | Lower extremity Fascial plane block |
64490 | Cervical/thoracic facet joint injection with/ guidance |
64633 | Neuroleptic destruction, cervical/thoracic nerve |
G3002 | Monthly chronic pain management service (HCPCS) |
These communal pain management CPT codes guarantee correct billing for injections, nerve blocks, and chronic pain care.
Note: CMS guidelines restrict frequency and require ≥50% pain relief documentation.
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Code | Description |
64466 – 64469 | Thoracic blocks via injection/infusion with imaging |
64473 – 64474 | Lower extremity blocks with imaging |
TAP & Rectus Sheath Blocks | Used for post-op abdominal pain control |
These newer codes reflect the trend toward image-guided pain relief techniques.
Key ICD-10 Codes for Pain Management:
Pairing accurate ICD-10 codes with the right CPT ensures cleaner claim submission and improved audit resilience.
CMS introduced G3002 and G3003 for chronic pain management:
These differ from CPT 99490 (chronic care management), highlighting CMS’s commitment to personalized pain care.
A patient with chronic shoulder pain (M25.511) receives an injection of corticosteroids.
Use CPT 20610 for the big joint injection and M25.511 as the ICD-10.
Always refer to payer-specific CMS pain management guidelines to stay compliant.
To boost accuracy and speed:
Medical billing for pain management doesn’t have to be complicated. Staying compliant with evolving CPT codes, changing CMS guidelines, and payer-specific rules can be challenging. That’s where Cures Medical Billing Services (CuresMB) steps in.
We specialize in simplifying billing for pain management clinics. Our experienced team ensures that every procedure, from nerve blocks to chronic care codes, is coded accurately and submitted cleanly to reduce denials and accelerate payments.
We offer:
Let’s exclude billing errors and improve your full revenue potential.
Contact CuresMB today, we’re ready to take your pain management billing to the next level.
They’re used to bill medical procedures related to diagnosing and treating pain, including injections, nerve blocks, and chronic care.
CPT codes define processes; ICD-10 codes describe the patient’s diagnosis.
Yes. Many codes like 64490 and 64633 have updated descriptors and now include imaging guidance.
These are CMS codes for chronic pain management, introduced to better manage long-term pain patients.
Use updated codes, document procedures correctly, and check payer-specific coverage rules.
Yes, for 1–2 groups. For 3 or more, use CPT 20553.
M54.5 for chronic low back pain and G89.29 for general chronic pain.
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